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TS ALLIANCE GRANTS PROGRAM

DESCRIPTION OF TSC FUNDING OPPORTUNITIES

• TS Alliance Research Grants Program (includes links to Requests for Applications and Letter of Intent Form)
• TS Alliance Rothberg Courage Award in Research

CURRENT TS ALLIANCE RESEARCH GRANT RECIPIENTS

Currently, the research portfolio of the TS Alliance focuses on basic, translational and clinical research in the areas of tuberin and hamartin basic function, epilepsy, angiogenesis, genetics, renal function, and behavior and cognition, as well as support for TSC and LAM clinical trials.

Grant Awards -- FY 2010

Aristotelis Astrinidis, PhD
Drexel University College of Medicine, Philadelphia, PA
Screen of FDA-Approved Drugs as a Therapeutic Approach for Tuberous Sclerosis Complex 
TSC Drug Screening Program

John Frangioni, MD, PhD
Beth Israel Deaconess Medical Center, Boston, MA
Quantitation of In Vivo Response in TSC Tumors: A National Resource of the TS Alliance
TSC Drug Screening Program

Samira Bahl, PhD
Sponsor:  Vijaya Ramesh, PhD
Massachusetts General Hospital, Boston, MA
Elucidating the Role of Structural Variations in Autism Associated with Tuberous Sclerosis Complex
Postdoctoral Fellowship Award

Alessia Di Nardo, PhD
Sponsor:  Mustafa Sahin, MD, PhD
Children’s Hospital, Harvard Medical School, Boston, MA
Regulation of Autophagy in Tuberous Sclerosis Complex
Postdoctoral Fellowship Award

Cary Fu, MD
Sponsor:  Kevin Ess, MD, PhD
Vanderbilt University, Nashville, TN
The Role of the Tsc1 Gene in Interneuron Differentiation and Migration
Postdoctoral Fellowship Award

Grant Awards -- FY 2009

Sandra Dabora, M.D., Ph.D.
Brigham & Women’s Hospital, Boston, MA
Supplement for TSC Preclinical Studies and Clinical Trials
TS Alliance Supplemental Funding Award

Petrus de Vries, MBChB, MRCPsych, Ph.D.
Cambridge University & Society for the Study of Behavioral Phenotypes (SSBP), Cambridge, UK
Listening to Genetic Disorders: The Etiology and Treatment of Neurodevelopmental Disorders
TS Alliance Conference Grant

June Goto, Ph.D.
Sponsor: David Kwiatkowski, M.D., Ph.D.
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Generation and Characterization of Genetic Models for Cortical Tubers
Postdoctoral Fellowship Award

Johnathan Lipton, M.D., Ph.D.
Sponsor: Mustafa Sahin, M.D., Ph.D.
Children’s Hospital, Boston, and Harvard Medical School, Boston, MA
Toward the Molecular Basis for Sleep Disorders in Tuberous Sclerosis Complex: The Circadian Link
Postdoctoral Fellowship Award

Guy McKhann, II, M.D.
Columbia University Medical Center, New York City, NY
Aberrant Astrocytic Control of Neuronal Excitability in Tuberous Sclerosis: A Potential Therapeutic Target in TSC Epileptic Syndrome
TSC Innovator Innovator Award

John-Claude Platel, Ph.D.
Sponsor: Angelique Bordey, Ph.D.
Yale University School of Medicine, New Haven, CT
Contributions of Neonatal Neural Progenitors to TSC Lesions
Postdoctoral Fellowship Award

Wei Qin, Ph.D.
Sponsor: David Kwiatkowski, M.D., Ph.D.
Brigham and Women’s Hospital, Harvard School of Medicine, Boston, MA
High Throughput Sequencing for Mutation Identification in TSC Genes
Postdoctoral Fellowship Award

Howard Weiner, M.D.
New York University Medical Center, New York, NY
Defining the Epileptogenic Zone in Tuberous Sclerosis Complex: Microelectrode Recordings in Children with Intractable Epilepsy and TSC
TSC Innovator Award

Raymond Yeung, M.D. 
University of Washington, Seattle, WA
Glucose Restriction in TSC
TSC Innovator Award

Yonghao Yu, Ph.D.
Sponsor: John Blenis, Ph.D. 
Harvard Medical School, Boston, MA
Characterization of the mTOR Signaling Pathways Using Quantitative Mass Spectrometry
Postdoctoral Fellowship Award

Grant Awards -- FY 2008

Linda DiBella, Ph.D.
Sponsor:  Sun, Ph.D.
Yale University, New Haven, CT
Investigating a Link Between the Cilium and the TSC/mTOR Pathway
Postdoctoral Fellowship Award

Cheryl Doughty, Ph.D.
Sponsor:  David Kwiatkowski, M.D., Ph.D.
Brigham & Women’s Hospital, Boston, MA
Investigation of TSC2 Missense Mutations
Postdoctoral Fellowship Award

Kevin Ess, M.D., Ph.D.
Vanderbilt University, Nashville, TN
Role of the Tuberin GAP Domain in Neural Progenitor Cells
Junior Investigator Award

Elizabeth Petri Henske, M.D.
Fox Chase Cancer Center, Philadelphia, PA
Roles of Tuberin (TSC2) and Rheb in Cystic Kidney Disease
PKD/TSC Research Award co-funded by the TS Alliance and the PKD Foundation

Arnold Kristoff, M.D.
McGill University, Montreal, Quebec, Canada
mTOR-containing Protein Complexes in the Pathogenesis of Tuberous Sclerosis
NIH Grant Award, Co-Funded by the National Cancer Institute, National Institutes of Health and the TS Alliance

Shao-Jun Tang, Ph.D.
University of California, Irvine, CA
Roles of TSC2 in Regulation of Dendritic Protein Synthesis and Synaptic Plasticity
Junior Investigator Award

Cheryl Walker, Ph.D.
M.D. Anderson Cancer Center, University of Texas, Smithville, TX
C-SRC Regulation of the Functional PKD-1 TSC2 Interaction
PKD/TSC Research Award co-funded by the TS Alliance and the PKD Foundation

Michael Wong, M.D., Ph.D.
Washington University, St. Louis, MO
Rational Therapy for Neurological Manifestations in a Mouse Model of TSC
Senior Investigator Award