TSC Alert

Archive for the ‘Research Resources’ Topic

TSC Biosamples Available at No Cost to Researchers

Are you looking for samples from TSC patients to use in your lab? The TSC Biosample Repository has a growing collection of samples tied to phenotypic data. In most cases, we can ship these samples at no charge to the investigator. By the end of 2018, we had shipped more than 400 samples for diverse projects, ranging from quantification of sphingolipids in plasma to investigating mitochondrial DNA heteroplasmy. As of February 7, 2019, the TSC Biosample Repository contained: 334 buccal cell samples for DNA isolation 193 blood samples from which plasma and white blood cells have been isolated 9 tissue…

Request Biosamples for Your Lab

Are you looking for samples from TSC patients to use in your lab? The TSC Biosample Repository has a growing collection of samples that are tied to phenotypic data. In most cases, we can ship these samples at no charge to the investigator.

Welcome to Our New Director of Preclinical Research

Please help us welcome Dean Aguiar, PhD, to the TS Alliance team! Dean is our new Director of Preclinical Research. He will lead the Preclinical Consortium’s future efforts, including the goal to partner with additional companies and academic researchers to help find new ways to treat the multiple, severe and sometimes life-threatening manifestations of TSC. He will also oversee other consortium objectives, including increasing the diversity of models available as well as adding models for TSC-associated neuropsychiatric disorders, an additional epilepsy model and human cell-based models.

Call for Proposals: TSC2+/- A/J Mice – Due October 22

The TSC Preclinical Consortium is currently running three animal models, one of which is the Tsc2+/- A/J strain (Woodrum et al 2010, Guo and Kwiatkowski 2013). Large cohorts of age-matched mice are bred for testing candidate drugs using standardized protocols at a contract research organization. However, as a by-product of growing the colony, we have smaller numbers of non-age-matched mice, which could provide valuable data for other research questions.

Call for Proposals: TSC2+/- A/J mice – Due May 4

The TSC Preclinical Consortium is currently running three animal models, one of which is the Tsc2+/- A/J strain (Woodrum et al 2010, Guo and Kwiatkowski 2013). A/J mice are challenging to breed, but the Preclinical Consortium’s colony at the Van Andel Research Institute is now in very good shape. Large cohorts of age-matched mice are bred for testing candidate drugs using standardized protocols at a contract research organization. However, as a by-product of growing the colony, we have smaller numbers of non-age-matched mice, which could provide valuable data for other research questions. We currently have available 31 female Tsc2+/- A/J…

New Sample Types Available in TSC Biosample Repository

The TS Alliance signed an agreement with Erasmus MC to include the TSC1- and TSC2-knockout HEK293T cell lines from the Nellist laboratory in the TSC Biosample Repository. The TS Alliance can distribute these cell lines to researchers based in the United States.