TSC Alert

Archive for the ‘Research Resources’ Topic

Call for Nominations: TSC Preclinical Consortium

The TSC Preclinical Consortium invites nominations of compounds to test in one of four animal models relevant to TSC. Epilepsy (spontaneous): Tsc1flox/flox;GFAP-Cre+ (GFAP-Tsc1-CKO) mice Tumor (graft): 105K (Tsc2-null) mouse cell grafts in mice Epilepsy (spontaneous): in utero electroporated RhebCA mice from Angelique Bordey’s lab Tumor (spontaneous): Tsc2+/- A/J mouse renal cystadenoma model

TSC Biosamples Available at No Cost to Researchers

Are you looking for samples from TSC patients to use in your lab? The TSC Biosample Repository has a growing collection of samples that are tied to phenotypic data. In most cases, we can ship these samples at no charge to the investigator. By the end of March 2019, we have shipped 678 samples for use in diverse projects, ranging from quantification of sphingolipids in plasma to investigating mitochondrial DNA heteroplasmy. As of March 31, 2019, the TSC Biosample Repository has collected: 342 buccal cell samples for DNA isolation 217 blood samples from which plasma and white blood cells have…

TSC Biosamples Available at No Cost to Researchers

Are you looking for samples from TSC patients to use in your lab? The TSC Biosample Repository has a growing collection of samples tied to phenotypic data. In most cases, we can ship these samples at no charge to the investigator. By the end of 2018, we had shipped more than 400 samples for diverse projects, ranging from quantification of sphingolipids in plasma to investigating mitochondrial DNA heteroplasmy. As of February 7, 2019, the TSC Biosample Repository contained: 334 buccal cell samples for DNA isolation 193 blood samples from which plasma and white blood cells have been isolated 9 tissue…

Request Biosamples for Your Lab

Are you looking for samples from TSC patients to use in your lab? The TSC Biosample Repository has a growing collection of samples that are tied to phenotypic data. In most cases, we can ship these samples at no charge to the investigator.

Welcome to Our New Director of Preclinical Research

Please help us welcome Dean Aguiar, PhD, to the TS Alliance team! Dean is our new Director of Preclinical Research. He will lead the Preclinical Consortium’s future efforts, including the goal to partner with additional companies and academic researchers to help find new ways to treat the multiple, severe and sometimes life-threatening manifestations of TSC. He will also oversee other consortium objectives, including increasing the diversity of models available as well as adding models for TSC-associated neuropsychiatric disorders, an additional epilepsy model and human cell-based models.

Call for Proposals: TSC2+/- A/J Mice – Due October 22

The TSC Preclinical Consortium is currently running three animal models, one of which is the Tsc2+/- A/J strain (Woodrum et al 2010, Guo and Kwiatkowski 2013). Large cohorts of age-matched mice are bred for testing candidate drugs using standardized protocols at a contract research organization. However, as a by-product of growing the colony, we have smaller numbers of non-age-matched mice, which could provide valuable data for other research questions.