iBiology is soliciting applications from PhD students and postdocs for its Young Scientist Seminars Competition.
The TSC Preclinical Consortium is currently running three animal models, one of which is the Tsc2+/- A/J strain (Woodrum et al 2010, Guo and Kwiatkowski 2013). Large cohorts of age-matched mice are bred for testing candidate drugs using standardized protocols at a contract research organization. However, as a by-product of growing the colony, we have smaller numbers of non-age-matched mice, which could provide valuable data for other research questions.
The TS Alliance is soliciting applications for seed funding for research using samples from the TSC Biosample Repository.
The TSC Preclinical Consortium invites nominations of compounds to test in one of three animal models relevant to TSC.
The TSC Preclinical Consortium is currently running three animal models, one of which is the Tsc2+/- A/J strain (Woodrum et al 2010, Guo and Kwiatkowski 2013). A/J mice are challenging to breed, but the Preclinical Consortium’s colony at the Van Andel Research Institute is now in very good shape. Large cohorts of age-matched mice are bred for testing candidate drugs using standardized protocols at a contract research organization. However, as a by-product of growing the colony, we have smaller numbers of non-age-matched mice, which could provide valuable data for other research questions. We currently have available 31 female Tsc2+/- A/J…
The TS Alliance signed an agreement with Erasmus MC to include the TSC1- and TSC2-knockout HEK293T cell lines from the Nellist laboratory in the TSC Biosample Repository. The TS Alliance can distribute these cell lines to researchers based in the United States.
2017 was a very productive year for advancing the science of tuberous sclerosis complex (TSC)! A very small sampling of our scientific community’s major accomplishments are highlighted below. The TS Alliance thanks all our grantees, collaborators, reviewers, conference attendees, International Scientific Advisory Board members, and Professional Advisory Board members for making these achievements possible.
California State University, Los Angeles is taking applications for its training program for early-stage bioscience startups until November 20. The LA BioStart Bioscience Entrepreneurs Boot Camp “addresses the challenges most common to scientists and new entrepreneurs seeking to turn their scientific discoveries into successful companies.” They encourage applications from university faculty, postdoctoral fellows and graduate students.
Having entered its second year, the TSC Biosample Repository is beginning to receive serial blood samples from individuals who donated one year ago. Although we have only three such serial samples today, we will continue to collect additional samples annually from more participants. These serial samples will be valuable for studies looking at changes in components of plasma over time in individuals with varying manifestations of TSC. This will hopefully lead to clinically useful biomarkers (e.g. markers of risk for various manifestations or response to treatment).
Our TSC Biosample Repository now has 329 biosamples, including 203 blood, buccal, or tissue samples from participants enrolled in the Natural History Database project. The Biosample Repository also includes blood samples from children and many of their parents collected by the TSC Clinical Research Consortium through the Developmental Synaptopathies Consortium and the PREVeNT trial. High-quality biospecimens and their associated clinical data will enable researchers to discover biomarkers, establish human cell lines or tissue arrays for drug testing, and search for clues to understand why TSC is so different from person to person.