Researchers

Grants and Funding

TS Alliance Research Grants Program

The TS Alliance endeavors to stimulate, support and coordinate research that will lead to a cure for tuberous sclerosis complex (TSC) while improving the lives of those affected. Most TS Alliance research grants support small, focused projects that allow investigators to develop preliminary data to compete for funding from larger organizations such as the National Institutes of Health (NIH).  Other TS Alliance research grants support post-doctoral fellowships to encourage young investigators to engage in TSC research.  Many of these investigators will continue to pursue TSC research when they establish their own independent laboratories.

Information about the 2017 grants cycle and process will be available in the Spring of 2017.

TS Alliance Indirect Costs Policy

For research grants, including postdoctoral fellowships, the TS Alliance allows no more than 10 percent of the total costs to be applied to indirect costs.  As an example, a maximum of $15,000 indirect costs may be included within an award totaling $150,000, of which at least $135,000 must therefore be direct costs.

The TS Alliance does not pay indirect costs on contracts based on delivering a tangible or measurable work product.  Examples of such contracts are those to enter data into the TSC Natural History Database.

Related TS Alliance Resources

Currently Funded Grant Awards

FY 2015

Postdoctoral Fellowship Award

Polina Kosillo, DPhil
Sponsor: Helen Bateup, PhD
University of California, Berkeley
The impact of Tsc1 deletion on dopamine neurons

Rothberg Courage Award

Brendan Manning, PhD
Harvard University School of Public Health
Repurposing approved inhibitors of purine synthesis for TSC treatment

Research Grant Award

Mustafa Sahin, MD, PhD
Boston Children’s Hospital
Sonic hedgehog and ciliary signaling in TSC

Andrew Tee, PhD
Cardiff University
Analysis of novel therapies and survival mechanisms in TSC2 deficient cells

FY 2014

Postdoctoral Fellowship Award

Gerta Hoxhaj, PhD
Sponsor: Brendan Manning, PhD
Harvard University School of Public Health, Boston, MA 
Role of the TSC complex component TBC1D7 in cell migration and invasion

Research Grant Award

Michael Higley, MD, PhD
Yale University, New Haven, CT
Analysis and treatment of altered cortical network dynamics in TSC

Sue Povey, MD, MA
University College London, London, UK
The TSC1 and TSC2 variation database

Co-funded with the Tuberous Sclerosis Association (UK)

Wei Shi, PhD
Children’s Hospital, Los Angeles, CA 
Lung mesenchymal TSC2 deletion in TSC lung disease

TSC Clinical Research Consortium

Mustafa Sahin, MD, PhD
Boston Children’s Hospital, Boston, MA
Administrative Core Support for Developmental Synaptopathies Associated with TSC, PTEN and SHANK3 Mutations

Five initial consortium sites received seed funding from the TS Alliance and two NIH grants for clinical studies to identify markers of risk for autism and infantile spasms in TSC. They are:

  • Boston Children’s Hospital
  • Cincinnati Children’s Hospital Medical Center
  • University of Alabama, Birmingham
  • University of California, Los Angeles
  • University of Texas, Houston

For Related Inquiries, Contact:

Katie Smith
Manager, Research and Global Affairs
Tuberous Sclerosis Alliance
801 Roeder Road, Suite 750
Silver Spring, MD  20910
Telephone:  1-800-225-6872 or 301-562-9890 ext. 214
E-mail: ksmith@tsalliance.org

Past Grant Awards

FY 2010

Postdoctoral Fellowship Award

Samira Bahl, PhD
Sponsor:  Vijaya Ramesh, PhD
Massachusetts General Hospital, Boston, MA
Elucidating the Role of Structural Variations in Autism Associated with Tuberous Sclerosis Complex

Alessia Di Nardo, PhD
Sponsor:  Mustafa Sahin, MD, PhD
Children’s Hospital, Harvard Medical School, Boston, MA
Regulation of Autophagy in Tuberous Sclerosis Complex

Cary Fu, MD
Sponsor:  Kevin Ess, MD, PhD
Vanderbilt University, Nashville, TN
The Role of the Tsc1 Gene in Interneuron Differentiation and Migration

TSC Drug Screening Program

Aristotelis Astrinidis, PhD
Drexel University College of Medicine, Philadelphia, PA
Screen of FDA-Approved Drugs as a Therapeutic Approach for Tuberous Sclerosis Complex 

John Frangioni, MD, PhD
Beth Israel Deaconess Medical Center, Boston, MA
Quantitation of In Vivo Response in TSC Tumors: A National Resource of the TS Alliance

TS Alliance Rothberg Courage Award in Research

Mustafa Sahin, MD, PhD
Children’s Hospital, Harvard Medical School, Boston, MA
TSC Neurocognitive Clinical Trial

Robert and Lisa Moss

Seizure Tracker, LLC, Alexandria, VA
Development and Implementation of an Epilepsy Clinical Trial Tool

FY 2009

Postdoctoral Fellowship Award

June Goto, PhD
Sponsor: David Kwiatkowski, MD, PhD
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Generation and Characterization of Genetic Models for Cortical Tubers

Johnathan Lipton, MD, PhD
Sponsor: Mustafa Sahin, MD, PhD
Children’s Hospital, Boston, and Harvard Medical School, Boston, MA
Toward the Molecular Basis for Sleep Disorders in Tuberous Sclerosis Complex: The Circadian Link

John-Claude Platel, PhD
Sponsor: Angelique Bordey, PhD
Yale University School of Medicine, New Haven, CT
Contributions of Neonatal Neural Progenitors to TSC Lesions

Wei Qin, PhD
Sponsor: David Kwiatkowski, MD, PhD
Brigham and Women’s Hospital, Harvard School of Medicine, Boston, MA
High Throughput Sequencing for Mutation Identification in TSC Genes

Yonghao Yu, PhD
Sponsor: John Blenis, PhD
Harvard Medical School, Boston, MA
Characterization of the mTOR Signaling Pathways Using Quantitative Mass Spectrometry

TSC Innovator Award

Guy McKhann, II, MD
Columbia University Medical Center, New York City, NY
Aberrant Astrocytic Control of Neuronal Excitability in Tuberous Sclerosis: A Potential Therapeutic Target in TSC Epileptic Syndrome

Howard Weiner, MD
New York University Medical Center, New York, NY
Defining the Epileptogenic Zone in Tuberous Sclerosis Complex: Microelectrode Recordings in Children with Intractable Epilepsy and TSC

Raymond Yeung, MD
University of Washington, Seattle, WA
Glucose Restriction in TSC

TS Alliance Rothberg Courage Award in Research

Frank McCormack, MD & Bruce Trapnell, MD
University of Cincinnati, Cincinnati, OH
MILES Trial

TS Alliance Conference Grant

Petrus de Vries, MBChB, MRCPsych, PhD
Cambridge University & Society for the Study of Behavioral Phenotypes (SSBP), Cambridge, UK
Listening to Genetic Disorders: The Etiology and Treatment of Neurodevelopmental Disorders

TS Alliance Supplemental Funding Award

Sandra Dabora, MD, PhD
Brigham & Women’s Hospital, Boston, MA
Supplement for TSC Preclinical Studies and Clinical Trials

FY 2008

Postdoctoral Fellowship Award

Linda DiBella, PhD
Sponsor:  Sun, Ph.D.
Yale University, New Haven, CT
Investigating a Link Between the Cilium and the TSC/mTOR Pathway

Cheryl Doughty, PhD
Sponsor:  David Kwiatkowski, MD, PhD
Brigham & Women’s Hospital, Boston, MA
Investigation of TSC2 Missense Mutations

Junior Investigator Award

Kevin Ess, MD, PhD
Vanderbilt University, Nashville, TN
Role of the Tuberin GAP Domain in Neural Progenitor Cells

Shao-Jun Tang, PhD
University of California, Irvine, CA
Roles of TSC2 in Regulation of Dendritic Protein Synthesis and Synaptic Plasticity

Senior Investigator Award

Michael Wong, MD, PhD
Washington University, St. Louis, MO
Rational Therapy for Neurological Manifestations in a Mouse Model of TSC

TS Alliance Rothberg Courage Award in Research

Frank McCormack, MD & Bruce Trapnell, MD
University of Cincinnati, Cincinnati, OH
MILES Trial

Other Funding

NIH Grant Award, Co-Funded by the National Cancer Institute, National Institutes of Health and the TS Alliance

Arnold Kristoff, MD
McGill University, Montreal, Quebec, Canada
mTOR-containing Protein Complexes in the Pathogenesis of Tuberous Sclerosis

PKD/TSC Research Award co-funded by the TS Alliance and the PKD Foundation

Elizabeth Petri Henske, MD
Fox Chase Cancer Center, Philadelphia, PA
Roles of Tuberin (TSC2) and Rheb in Cystic Kidney Disease

Cheryl Walker, PhD

M.D. Anderson Cancer Center, University of Texas, Smithville, TX
C-SRC Regulation of the Functional PKD-1 TSC2 Interaction

FY 2007

TS Alliance Rothberg Courage Award in Research

Frank McCormack, MD & Bruce Trapnell, MD 

University of Cincinnati, Cincinnati, OH
MILES Trial  

FY 2002 – 2005

TS Alliance Rothberg Courage Award in Research

John Blenis, PhD
Lewis Cantley, PhD
Iswar Hariharan, MBBS, PhD
David Kwiatkowski, MD, PhD
Timothy Mitchison, PhD

Harvard Medical School and Brigham & Women’s Hospital, Boston, MA
Role of the TSC1/2 Complex in Regulation of the mTOR Pathway

David Austin, PhD
Yale University, New Haven, CT
Screening of Potential Therapeutics for TSC

Tian Xu, PhD
Yale University, New Haven, CT
Role of the TSC/Insulin Signaling Pathway in the Pathogenesis of TSC

Elizabeth Petri Henske, MD
Fox Chase Cancer Center, Philadelphia, PA
Effects of Estrogen and Progesterone on Angiomyolipoma Growth and Migration

For Related Inquiries, Contact:

Katie Smith
Senior Associate, Science and Government Affairs
Tuberous Sclerosis Alliance
801 Roeder Road, Suite 750
Silver Spring, MD  20910
Telephone:  1-800-225-6872 or 301-562-9890 ext. 214
E-mail: ksmith@tsalliance.org

Other TSC Funding Opportunities

Additional funding opportunities for TSC research may be available through the federal agencies and non-federal organizations listed below.  The TS Alliance also looks to collaborate with other organizations that have shared research priorities and are interested in partnering or co-funding opportunities.

If you would like to add your organization to the list below or are interested in the possibility of exploring co-funding opportunities, please contact Steve Roberds at sroberds@tsalliance.org.

AES Early Career Research Fellowships and Grants: Letters of Intent due October 5, 2016

As one of the largest non-governmental funders for those starting their careers in epilepsy research, the American Epilepsy Society (AES) is committed to developing the next generation of epilepsy investigators. Our early career funding programs include Predoctoral Research Fellowships, Postdoctoral Research Fellowships, and Research and Training Fellowships for Clinicians, as well as Junior Investigator Research Awards for newly independent investigators. Letters of Intent for all programs are due October 5, 2016, and full applications will be due January 31, 2017. For complete program guidelines and application instructions, see https://www.aesnet.org/research/Early_Career_Funding.

Federal Funding

Non-Federal Funding

For Related Inquiries or to Have Your Organization Listed, Contact:

Katie Smith
Senior Associate, Science and Government Affairs
Tuberous Sclerosis Alliance
801 Roeder Road, Suite 750
Silver Spring, MD  20910
Telephone:  1-800-225-6872 or 301-562-9890 ext. 214
E-mail: ksmith@tsalliance.org