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The TS Alliance has funded more than $16.5 million in research on TSC since 1984. The TS Alliance Research Grants Program funds research focused on TSC with priorities set by the researchers together with the TS Alliance.  Collaborations between basic and clinical researchers are encouraged and fostered, and the TS Alliance is working to increase funding for research on TSC. Download an analysis of the impact of the TS Alliance Research Grants Program from 1984-2010.

TS Alliance 2013 Research Grants Program

The deadline for submission of Letters of Intent for this program has passed.  Please see our Rothberg Courage Award in Research opportunity that is accepting Letters of Intent through September 23, 2013.  Also, please check this page in early 2014 for information on our 2014 Research Grants Program.

The Tuberous Sclerosis Alliance (TS Alliance) endeavors to stimulate, support and coordinate research that will lead to a cure for tuberous sclerosis complex (TSC), while improving the lives of those affected.  A recent white paper describes the impressive scientific progress in the field and highlights key TSC research needs for the future.


The TS Alliance Research Grants Program supports basic research by postdoctoral scientists and studies that accelerate the translation of basic research findings into improvements in quality of life for those affected by TSC.  Researchers funded by the TS Alliance have a strong history of obtaining additional funding: between 1984 and 2010, principal investigators who received a total of $8.7 million from the TS Alliance garnered an additional $60 million from the NIH for TSC-related research and $6.9 million from the Department of Defense’s Congressionally Directed Medical Research Program.

Areas of Emphasis in 2013

Successful proposals will be those that address one or more of the following:

  • Developing future TSC researchers and clinician scientists through postdoctoral fellowships
  • Development of biomarkers to enable more robust and efficient clinical studies
  • Methods of eliminating tumors rather than only shrinking or stabilizing tumor growth
  • Neurological, cognitive, or behavioral manifestations of TSC

Key Dates

  • Full Proposals Due (by invitation only): September 5, 2013, at 11:59 p.m. U.S. EDT. Download instructions for online submission here
  • Award Notification: October 9, 2013
  • Earliest Funding Start Date: December 1, 2013

Funding Available

  • Duration: up to two years (can be shorter if appropriate for the project)
  • Budget limits:
    • Maximum total costs of $66,000 per year ($132,000 total) inclusive of both direct and indirect costs
    • No more than 10 percent of the total costs ($6,600 per year or $13,200 total) may be applied to indirect costs
  • Postdoctoral fellowship awards must include $1,000 for travel expenses to support the applicant’s professional development

The TS Alliance anticipates making three awards this year in some combination of postdoctoral fellowships or research proposals, depending on merit.

Postdoctoral fellowship awards are designed to provide funding for a PI who has recently earned a PhD or MD degree and is working with a Sponsor to do research relevant to this Request for Letters of Intent.  The Sponsor must be tenure-track faculty or an equivalent level at a research institution or company.  The award is intended to fund the Principal Investigator’s salary and some of the laboratory supplies or tools necessary to conduct the proposed research.  The award is not intended to fund technical support for the project or to purchase equipment in the Sponsor’s laboratory.


This opportunity is open to all investigators at established academic or research institutions or at pharmaceutical or biotech companies worldwide.  Researchers residing in the U.S. do not need to be U.S. citizens to apply for funding.

Required Components of the Grant Application

  • PI contact information and, if a postdoctoral fellowship application, a Sponsor.
  • Key Personnel contact information for collaborating independent investigators or sub-contractors.
  • In lay language, a summary of the proposed research and a statement of the impact the research will have on individuals who have TSC.
  • A technical abstract.
  • One to four specific aims.
  • A research concept proposal including the rationale, the concept of how the research will be carried out, potential impact of the proposed work, and references (if needed).  The research concept proposal must:
    • be in a PDF format and not exceed 10 letter- or A4-size pages,
    • have no smaller than a 0.5-inch margin on all sides, and
    • use a readable font meeting NIH requirements, specifically 11 points or larger using Georgia, Palatino, Arial, or Helvetica font.
    • Any tables, figures, or references must fit within the two-page limit.
  • Budget justification meeting the above formatting requirements. 
  • Budget Period Detail for each year of the project, entered online. 
  • Other support for the applicant and Key Personnel, entered online. 
  • An NIH-style biosketch of the PI and, if a postdoctoral application, the Sponsor; this form is available at:
  • The components above must be submitted online prior to September 5, 2013, at 11:59 p.m. US EDT.
  • A signature page printed from proposalCENTRAL signed by the applicant (and by the Sponsor for a postdoctoral fellowship application) and by a signing official for the institution, faxed to Katie Smith at 301-562-9870 or scanned into PDF format and emailed to by the online submission deadline.

This information and a description of research funded by previous awards are available here.

For Related Inquiries, Contact:

Steve Roberds, PhD  
Chief Scientific Officer
Tuberous Sclerosis Alliance 
801 Roeder Road, Suite 750 
Silver Spring, MD  20910 
Telephone:  1-800-225-6872 or 301-562-9890 ext. 225 

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