About TSC

TSC-Associated Neuropsychiatric Disorders (TAND)

TSC is associated with a wide range of cognitive, behavioral, and psychiatric manifestations. TAND is a new terminology proposed to describe the interrelated functional and clinical manifestations of brain dysfunction in TSC, including aggressive behaviors, autism spectrum disorder (ASD), intellectual disabilities, psychiatric disorders, neuropsychological deficits, as well as school and occupational difficulties.

TSC is the genetic disorder most commonly associated with ASD, and suggestions of language and communication difficulties, reciprocal social interaction difficulties, and unusual patterns of behavior and play should trigger a careful developmental evaluation as soon as they are noted.

Experts at the 2012 TSC Clinical Consensus Conference recommended all individuals be screened for TAND upon diagnosis and at least annually. More detailed evaluations should follow from screening. Every individual with TSC should also have a comprehensive formal evaluation at key developmental timepoints (i.e., infancy, toddler, pre-school, early school years, middle school years, adolescence, adulthood).

The TAND Checklist

The TAND Checklist was developed to help clinical teams, individuals with TSC and their families screen for TAND at every clinic visit and prioritize what to do next.

Those wishing to translate the TAND Checklist into another language should download the following documents and follow the instructions:


For more information, please send email to TANDchecklist@gmail.com.